作为中药治疗失眠的首选药物，酸枣仁已有两千多年的临床使用历史，其道地药材产地在我国华北地区；理枣仁为近现代用药，主要分布在我国西南地区。近年来，由于二者性状特征相近，功效相似，但市场价格差异较大，从而导致理枣仁（甚至枳椇子、染色扁豆）冒充或掺伪酸枣仁的现象较为普遍，在中药材市场及临床应用中较为混乱。As the first choice of traditional Chinese medicine for the treatment of insomnia, Ziziphi Spinosae Semen (ZSS) has a clinical history of over 2,000 years, and its authentic medicinal materials are produced in the northern region of China. In contrast, Ziziphi Mauritianae Semen (ZMS) is a modern medicine mainly distributed in the southwestern region of China. In recent years, due to the similar morphological characteristics and therapeutic effects of the two herbs, but a significant difference in market prices, it has become increasingly common for ZMS to be fraudulently labeled or adulterated as ZSS, leading to confusion in the Chinese herbal medicine market and clinical applications.那么，二者究竟有何特点？如何准确区分酸枣仁和理枣仁呢？What are the characteristics that distinguish ZSS from ZMS, and how can they be accurately distinguished?0101药典收录与性味归经酸枣仁 （Ziziphi Spinosae Semen，ZSS）为鼠李科枣属植物酸枣 Z. jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow的干燥成熟种子，始载于《神农本草经》，位列上品，历代本草皆有收录。其味甘、酸，性平，归肝、胆、心经，具有养心补肝、宁心安神、敛汗、生津之功效。作为中药治疗失眠的首选药物，酸枣仁在治疗失眠相关的药方中使用率高达70%以上。理枣仁 （Ziziphi Mauritianae Semen，ZMS）为酸枣仁同科同属植物滇刺枣 Z. mauritiana Lam. 的干燥成熟种子，也称“滇枣仁”、“缅枣仁”或“进口酸枣仁”等，为近现代用药，仅在《滇南本草》中有过收录。其味甘、平，归心、肝经，具有宁心安神，除烦敛汗的功效。在云南民间被作为治疗失眠的习用药材使用。1 Pharmacopoeia Inclusion and CategorizationZSS, also known as sour jujube seed, is the dried mature seed of the plant Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow, which belongs to the Rhamnaceae family. It was first recorded in the classic Chinese herbal book "Shennong Bencao Jing" and was listed as a top-grade herb. It has been included in nearly all Chinese pharmacopoeias throughout history. ZSS is associated with the liver, gallbladder, and heart meridians, possess the effects of nourishing the heart and liver, calming the mind and tranquilizing the nerves, according to the theory of Traditional Chinese Medicines. As the first choice for treating insomnia in Traditional Chinese Medicines, ZSS is used in over 70% of insomnia-related prescriptions.ZMS, also known as "Dian zao ren", "Mian zao ren", or "imported sour jujube kernel", is the dried mature seed of Ziziphi mauritiana Lam., a plant belonging to the same family and genus as ZSS, but a different species. It is a relatively modern medicinal material and has only been recorded in the "Dian Nan Ben Cao". ZMS is associated with the heart and liver meridians, and is known for its calming and sweat-reducing effects, according to TCMs. ZMS is commonly used in Yunnan folk medicine to treat insomnia.02真假酸枣仁的化学成分差异现代药理学研究表明，酸枣仁和理枣仁均富含三萜皂苷、黄酮、生物碱和核苷类化学成分，但所含化合物的种类和含量差异明显。2 Chemical Differences between ZSS and ZMSIt has been discovered by modern pharmacological research that both ZSS and ZMS are rich in triterpenoids, flavonoids, alkaloids, and nucleoside. However, there are…
